Basic Research in Cardiology OnlineFirst articles

Open Access 30.05.2024 | Original Contribution

Targeting Gαi2 in neutrophils protects from myocardial ischemia reperfusion injury

Neutrophils are not only involved in immune defense against infection but also contribute to the exacerbation of tissue damage after ischemia and reperfusion. We have previously shown that genetic ablation of regulatory Gαi proteins in mice has …

verfasst von:: David Köhler, Veronika Leiss, Lukas Beichert, Simon Killinger, Daniela Grothe, Ragini Kushwaha, Agnes Schröter, Anna Roslan, Claudia Eggstein, Jule Focken, Tiago Granja, Vasudharani Devanathan, Birgit Schittek, Robert Lukowski, Bettina Weigelin, Peter Rosenberger, Bernd Nürnberg, Sandra Beer-Hammer

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Open Access 25.05.2024 | Original Contribution

Vasodilator reactive oxygen species ameliorate perturbed myocardial oxygen delivery in exercising swine with multiple comorbidities

Multiple common cardiovascular comorbidities produce coronary microvascular dysfunction. We previously observed in swine that a combination of diabetes mellitus (DM), high fat diet (HFD) and chronic kidney disease (CKD) induced systemic …

verfasst von:: R. W. A. van Drie, J. van de Wouw, L. M. Zandbergen, J. Dehairs, J. V. Swinnen, M. T. Mulder, M. C. Verhaar, A. MaassenVanDenBrink, D. J. Duncker, O. Sorop, D. Merkus

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21.05.2024 | Original Contribution

Chronic kidney disease activates the HDAC6-inflammatory axis in the heart and contributes to myocardial remodeling in mice: inhibition of HDAC6 alleviates chronic kidney disease-induced myocardial remodeling

Chronic kidney disease (CKD) adversely affects the heart. The underlying mechanism and the interplay between the kidney and the heart are still obscure. We examined the cardiac effect using the unilateral ureteral obstruction (UUO)-induced CKD …

verfasst von:: Sourav Kundu, Shobhit Gairola, Smriti Verma, Madhav Nilakanth Mugale, Bidya Dhar Sahu

17.05.2024 | Mitochondria at the heart of cardioprotection

Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat

The right ventricle (RV) differs developmentally, anatomically and functionally from the left ventricle (LV). Therefore, characteristics of LV adaptation to chronic pressure overload cannot easily be extrapolated to the RV. Mitochondrial …

verfasst von:: Ling Li, Bernd Niemann, Fabienne Knapp, Sebastian Werner, Christian Mühlfeld, Jan Philipp Schneider, Liane M. Jurida, Nicole Molenda, M. Lienhard Schmitz, Xiaoke Yin, Manuel Mayr, Rainer Schulz, Michael Kracht, Susanne Rohrbach

09.05.2024 | Original Contribution

Connexin 43 modulates reverse electron transfer in cardiac mitochondria from inducible knock-out Cx43Cre−ER(T)/fl mice by altering the coenzyme Q pool

Succinate accumulates during myocardial ischemia and is rapidly oxidized during reperfusion, leading to reactive oxygen species (ROS) production through reverse electron transfer (RET) from mitochondrial complex II to complex I, and favoring cell …

verfasst von:: Marta Consegal, Elisabet Miró-Casas, Ignasi Barba, Marisol Ruiz-Meana, Javier Inserte, Begoña Benito, Cristina Rodríguez, Freddy G. Ganse, Laura Rubio-Unguetti, Carmen Llorens-Cebrià, Ignacio Ferreira-González, Antonio Rodríguez-Sinovas

09.05.2024 | Cardio-Oncology

The role and mechanism of epigenetics in anticancer drug-induced cardiotoxicity

Cardiovascular disease is the main factor contributing to the global burden of diseases, and the cardiotoxicity caused by anticancer drugs is an essential component that cannot be ignored. With the development of anticancer drugs, the survival …

verfasst von:: Xuening Liu, Zijian Li

Open Access 19.04.2024 | Original Contribution

Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival

Hypertrophic cardiomyopathy (HCM) constitutes the most common genetic cardiac disorder. However, current pharmacotherapeutics are mainly symptomatic and only partially address underlying molecular mechanisms. Circular RNAs (circRNAs) are a …

verfasst von:: Dimyana Neufeldt, Arne Schmidt, Elisa Mohr, Dongchao Lu, Shambhabi Chatterjee, Maximilian Fuchs, Ke Xiao, Wen Pan, Sarah Cushman, Christopher Jahn, Malte Juchem, Hannah Jill Hunkler, Giuseppe Cipriano, Bjarne Jürgens, Kevin Schmidt, Sonja Groß, Mira Jung, Jeannine Hoepfner, Natalie Weber, Roger Foo, Andreas Pich, Robert Zweigerdt, Theresia Kraft, Thomas Thum, Christian Bär

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02.04.2024 | Original Contribution

Exercise training decreases lactylation and prevents myocardial ischemia–reperfusion injury by inhibiting YTHDF2

Exercise improves cardiac function and metabolism. Although long-term exercise leads to circulating and micro-environmental metabolic changes, the effect of exercise on protein post-translational lactylation modifications as well as its functional …

verfasst von:: Gui-e Xu, Pujiao Yu, Yuxue Hu, Wensi Wan, Keting Shen, Xinxin Cui, Jiaqi Wang, Tianhui Wang, Caiyue Cui, Emeli Chatterjee, Guoping Li, Dragos Cretoiu, Joost P. G. Sluijter, Jiahong Xu, Lijun Wang, Junjie Xiao

Open Access 30.03.2024 | Original Contribution

Role of inflammatory signaling pathways involving the CD40–CD40L–TRAF cascade in diabetes and hypertension—insights from animal and human studies

CD40L–CD40–TRAF signaling plays a role in atherosclerosis progression and affects the pathogenesis of coronary heart disease (CHD). We tested the hypothesis that CD40L–CD40–TRAF signaling is a potential therapeutic target in hyperlipidemia …

verfasst von:: Lea Strohm, Andreas Daiber, Henning Ubbens, Roopesh Krishnankutty, Matthias Oelze, Marin Kuntic, Omar Hahad, Veronique Klein, Imo E. Hoefer, Alex von Kriegsheim, Hartmut Kleinert, Dorothee Atzler, Philipp Lurz, Christian Weber, Philipp S. Wild, Thomas Münzel, Christoph Knosalla, Esther Lutgens, Steffen Daub

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Open Access 23.03.2024 | Cardio-Oncology

Early microvascular coronary endothelial dysfunction precedes pembrolizumab-induced cardiotoxicity. Preventive role of high dose of atorvastatin

Immune checkpoint inhibitors (ICIs) exhibit remarkable antitumor activity and immune-related cardiotoxicity of unknown pathomechanism. The aim of the study was to investigate the ICI class-dependent cardiotoxicity in vitro and pembrolizumab’s …

verfasst von:: Panagiotis Efentakis, Angeliki Choustoulaki, Grzegorz Kwiatkowski, Aimilia Varela, Ioannis V. Kostopoulos, George Tsekenis, Ioannis Ntanasis-Stathopoulos, Anastasios Georgoulis, Constantinos E. Vorgias, Harikleia Gakiopoulou, Alexandros Briasoulis, Constantinos H. Davos, Nikolaos Kostomitsopoulos, Ourania Tsitsilonis, Meletios Athanasios Dimopoulos, Evangelos Terpos, Stefan Chłopicki, Maria Gavriatopoulou, Ioanna Andreadou

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Open Access 14.03.2024 | Cardio-Oncology

Characterization of anthracycline-induced cardiotoxicity by diffusion tensor magnetic resonance imaging

Anthracyclines are highly potent anti-cancer drugs, but their clinical use is limited by severe cardiotoxic side effects. The impact of anthracycline-induced cardiotoxicity (AIC) on left ventricular (LV) microarchitecture and diffusion properties …

verfasst von:: David Lohr, Arne Thiele, Max Stahnke, Vera M. Braun, Robert Klopfleisch, Oliver Klein, Sandra Dresen, Ulf Landmesser, Anna Foryst-Ludwig, Ulrich Kintscher, Laura M. Schreiber, Niklas Beyhoff

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Open Access 14.02.2024 | Cardio-Oncology

Exercise, cancer, and the cardiovascular system: clinical effects and mechanistic insights

Cardiovascular diseases and cancer are the leading causes of death in the Western world and share common risk factors. Reduced cardiorespiratory fitness (CRF) is a major determinant of cardiovascular morbidity and cancer survival. In this review …

verfasst von:: Simon Wernhart, Tienush Rassaf

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