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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 6/2018

01.06.2018 | Pediatric Allergy and Immunology (W Dolen, Section Editor)

Severe Atopic Dermatitis in Children

verfasst von: Evie Huang, Peck Y. Ong

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 6/2018

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Abstract

Purpose of Review

Severe atopic dermatitis (AD) in childhood leads to significant morbidity including psychosocial problems and infectious complications. There are only a few approved treatment options for these patients. These include topical corticosteroids and tacrolimus ointment, which are associated with potential side effects.

Recent Findings

In order to find better and safer treatments, further understanding of AD mechanisms is needed. Primary skin barrier defects play an important role in the pathogenesis of AD. In addition, the suppression of skin barrier functions by Th2 inflammation also plays an important role in the persistence and recurrence of AD. Cytokines in the Th2 pathway, which includes IL-4, IL-13, TSLP, IL-25, IL-31, and IL-33, are potential therapeutic targets in AD. Other potential targets of AD are Janus kinase, phospholipase A2, aryl hydrocarbon receptor, and skin microbiota.

Summary

A better understanding of the pathogenesis of AD will provide future direction for treatment.
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Metadaten
Titel
Severe Atopic Dermatitis in Children
verfasst von
Evie Huang
Peck Y. Ong
Publikationsdatum
01.06.2018
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 6/2018
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-018-0788-4

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